Structure of PDB 6g1s Chain A Binding Site BS02

Receptor Information
>6g1s Chain A (length=645) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPYQMEVAQPALDGKNIIICLPTGSGKTRVAVYITKDHLDKKKQASESGK
VIVLVNKVMLAEQLFRKEFNPYLKKWYRIIGLSGDTQLKISFPEVVKSYD
VIISTAQILENSLLNLESGDDDGVQLSDFSLIIIDECHHTNKEAVYNNIM
RRYLKQKLRNNDLKAIPLPQILGLTASPGVGAAKKQSEAEKHILNICANL
DAFTIKTVKENLGQLKHQIKEPCKKFVIANPFKEKLLEIMASIQTYCQKS
PMSDFGTQHYEQWAIQMEKKAAKDGNRKDRVCAEHLRKYNEALQINDTIR
MIDAYSHLETFYTDEKEKKFAVLNDETDEFLMNLFFDNKKMLKKLAENPK
EKLIKLRNTILEQFTRSSRGIIFTKTRQSTYALSQWIMENAKVKAHHLIG
AGHSSEVKPMTQTEQKEVISKFRTINLLIATTVAGLDIKECNIVIRYGLV
TNEIAMVQARGRARADESTYVLVTSSGVTEREIVNDFREKMMYKAINRVQ
NMKPEEYAHKILELQVQSILEKKMKVKRSIAKQYNDNPSLITLLCKNCSM
LVCSGENIHVIEKMHHVNMTPEFKGLYIVRENKTNGEIICKCGQAWGTMM
VHKGLDLPCLKIRNFVVNFSPKKQYKKWVELPIRFPDLDYSEYCL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6g1s Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
Resolution3.93 Å
Binding residue
(original residue number in PDB)		N365 K366 V367 G393 Q416 E580 Q581 K726 T727 R728 I755 G756 A757 S761 T789 T790 V791 E924 M926 K975
Binding residue
(residue number reindexed from 1)		N56 K57 V58 G84 Q107 E261 Q262 K375 T376 R377 I399 G400 A401 S405 T431 T432 V433 E562 M564 K603
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:6g1s, PDBe:6g1s, PDBj:6g1s
PDBsum6g1s
PubMed30449722
UniProtQ8R5F7|IFIH1_MOUSE Interferon-induced helicase C domain-containing protein 1 (Gene Name=Ifih1)

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