Structure of PDB 6g1e Chain A Binding Site BS02

Receptor Information

>6g1e Chain A (length=208) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFKWYVDGVEVHN
AKTKPREEQYNSTFRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTI
SKTKGQPREPAVYTLPPSREEMTKNQVKLVCLVTGFYPSDIAVEWESSGQ
PENNYYTTPPMLDSDGSFSLVSWLNVDKSRWQQGNIFSCSVMHEALHNRF
TQKSLSLS

Ligand information

Ligand ID

GAL

InChI

InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6-/m1/s1

InChIKey

WQZGKKKJIJFFOK-FPRJBGLDSA-N

SMILES

Software	SMILES
CACTVS 3.370	OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O
OpenEye OEToolkits 1.7.2	C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.370	OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
ACDLabs 12.01	OC1C(O)C(OC(O)C1O)CO
OpenEye OEToolkits 1.7.2	C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O)O)O)O)O

Formula

C6 H12 O6

Name

beta-D-galactopyranose;
beta-D-galactose;
D-galactose;
galactose

PDB chain

6g1e Chain C Residue 6 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	6g1e A single mutation increases heavy chain heterodimer assembly of bispecific antibodies by inducing structural disorder in one homodimer species.
Resolution	1.88 Å
Binding residue (original residue number in PDB)	E258 T260
Binding residue (residue number reindexed from 1)	E22 T24
Annotation score	4

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:6g1e, PDBe:6g1e, PDBj:6g1e
PDBsum	6g1e
PubMed	32404368
UniProt	P01857\|IGHG1_HUMAN Immunoglobulin heavy constant gamma 1 (Gene Name=IGHG1); P01860\|IGHG3_HUMAN Immunoglobulin heavy constant gamma 3 (Gene Name=IGHG3)

[Back to BioLiP]