Structure of PDB 6g19 Chain A Binding Site BS02

Receptor Information
>6g19 Chain A (length=682) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LQLRPYQMEVAQPALDGKNIIICLPTGSGKTRVAVYITKDHLDKKKQASE
SGKVIVLVNKVMLAEQLFRKEFNPYLKKWYRIIGLSGDTQLKISFPEVVK
SYDVIISTAQILENSLLNLESGDDDGVQLSDFSLIIIDECHHTNKEAVYN
NIMRRYLKQKLRNNDLKKAIPLPQILGLTASPGVGAAKKQSEAEKHILNI
CANLDAFTIKTVKENLGQLKHQIKEPCKKFVIADDTRENPFKEKLLEIMA
SIQTYCQKSPMSDFGTQHYEQWAIQMEKKAAKDGNRKDRVCAEHLRKYNE
ALQINDTIRMIDAYSHLETFYTDEKEKKFAVLNKLDETDEFLMNLFFDNK
KMLKKLAENPKYENEKLIKLRNTILEQFTRSEESSRGIIFTKTRQSTYAL
SQWIMENAKFAEVGVKAHHLIGAGHSSEVKPMTQTEQKEVISKFRTGEIN
LLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVT
SSGSGVTEREIVNDFREKMMYKAINRVQNMKPEEYAHKILELQVQSILEK
KMKVKRSIAKQYNDNPSLITLLCKNCSMLVCSGENIHVIEKMHHVNMTPE
FKGLYIVRENKALQKYQTNGEIICKCGQAWGTMMVHKGLDLPCLKIRNFV
VNFKNNSPKKQYKKWVELPIRFPDLDYSEYCL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6g19 Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
Resolution3.68 Å
Binding residue
(original residue number in PDB)		N365 V367 G393 K398 T414 Q416 R606 K726 R728 G756 S761 T789 T790 V791 E924 V973
Binding residue
(residue number reindexed from 1)		N59 V61 G87 K92 T108 Q110 R296 K392 R394 G422 S427 T455 T456 V457 E590 V635
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:6g19, PDBe:6g19, PDBj:6g19
PDBsum6g19
PubMed30449722
UniProtQ8R5F7|IFIH1_MOUSE Interferon-induced helicase C domain-containing protein 1 (Gene Name=Ifih1)

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