Structure of PDB 6g0a Chain A Binding Site BS02

Receptor Information
>6g0a Chain A (length=1104) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NNYALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVG
WLTNMHATLVSQETNQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDE
SRVNDVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNS
NQLFEARKLLRPILQDNARNIYNVDAKHLIEDIREYDVPYHVRVSIDKDI
RVGKWYKVTQQGFIEDTRKIAFADPVVMAFDIETTKPPLKFRDSAVDQIM
MISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVALL
QRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPDAE
GEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPELM
TPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETLR
KGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGHVE
SLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVTN
FEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRLQPDSI
KAERTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNKKKVLTFDEL
SYADQVIHIKKRLTEYSRKVYHRVKVSEIVEREAIVCQRENPFYVDTVKS
FRDRRYEFKGLAKTWKGNLSKHARDEAKKMIVLYDSLQLAHKVILNSFYG
YVMRKGSRWYSMEMAGITCLTGATIIQMARALVERVGRPLELDTDGIWCI
LPKSFPETYFFTLENGKKLYLSYPCSMLNYRVHQKFTNHQYQELKDPLNY
IYETHSENTIFFEVDGPYKAMILPSSKEEGKGIKKRYAVFNEDGSLAELK
GFELKRRGELQLIKNFQSDIFKVFLEGDTLEGCYSAVASVCNRWLDVLDS
HGLMLEDEDLVSLICENRSMSKTLKEYEGQKSTSITTARRLGDFLGEDMV
KDKGLQCKYIISSKPFNAPVTERAIPVAIFSADIPIKRSFLRRWTLDPSL
EDLDIRTIIDWGYYRERLGSAIQKIITIPAALQGVSNPVPRVEHPDWLKR
KIAT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6g0a Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon.
Resolution2.62 Å
Binding residue
(original residue number in PDB)		T512 G513 T514 T552 Y553 G555 G556 V558 R686 S829 G832 M835 R836 K837 I965 K966 K967 R988 K1063 T1103 Y1145 R1149 K1156
Binding residue
(residue number reindexed from 1)		T453 G454 T455 T493 Y494 G496 G497 V499 R615 S747 G750 M753 R754 K755 I883 K884 K885 R906 K981 T1021 Y1063 R1067 K1074
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6g0a, PDBe:6g0a, PDBj:6g0a
PDBsum6g0a
PubMed30670696
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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