Structure of PDB 6fwk Chain A Binding Site BS02

Receptor Information
>6fwk Chain A (length=1103) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWLT
NMHATLVSQEQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESRVND
VEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQLFE
ARKLLRPILQDNANNNVQRNIYNKVDAKHLIEDIREYDVPYHVRVSIDKD
IRVGKWYKVTQQGFIEDTRKIAFADPVVMAFDIETTKPPLKFPDSAVDQI
MMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVAL
LQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPDA
EGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPEL
MTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETL
RKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGHV
ESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVT
NFEEIKNQITQKLLELKENNIRNELPLIYHVDVASGYPNIMTTNRLQPDS
IKTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPVLTFDELSYADQV
IHIKKRLTEYSRKVYHRVKVSEIVEREAIVCQRENPFYVDTVKSFRDRRY
EFKGLAKTWKGNLSKIDPSDKHARDEAKKMIVLYDSLQLAHKVILNSFYG
YVMRKGSRWYSMEMAGITCLTGATIIQMARALVERVGRPLELDTDGIWCI
LPKSFPETYFFTLENGKKLYLSYPCSMLNYRVHQKFTNHQYQELKDPLNY
IYETHSENTIFFEVDGPYKAMILPSSKEEGKGIKKRYAVFNEDGSLAELK
GFELKRRGELQLIKNFQSDIFKVFLEGDTLEGCYSAVASVCNRWLDVLDS
HGLMLEDEDLVSLICENRSMSKTLKEYEGQKSTSITTARRLGDFLGEDMV
KDKGLQCKYIISSKPFNAPVTERAIPVAIFSADIPIKRSFLRRWTLDPSL
EDLDIRTIIDWGYYRERLGSAIQKIITIPAALQGVSNPVPRVEHPDWLKR
KIA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6fwk Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon.
Resolution2.503 Å
Binding residue
(original residue number in PDB)		K510 G511 T512 G513 T514 T552 Y553 G555 G556 V558 R686 R744 S829 G832 M835 R836 K837 K966 K967 R968 R988 K1063 T1103 Y1145 K1156
Binding residue
(residue number reindexed from 1)		K452 G453 T454 G455 T456 T494 Y495 G497 G498 V500 R613 R662 S747 G750 M753 R754 K755 K884 K885 R886 R906 K981 T1021 Y1063 K1074
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6fwk, PDBe:6fwk, PDBj:6fwk
PDBsum6fwk
PubMed30670696
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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