Structure of PDB 6fw2 Chain A Binding Site BS02

Receptor Information
>6fw2 Chain A (length=444) Species: 9606,10665 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MQQVGTVAQLWIYPVKSCKGVPVSEAECTAMGLRSGNLRDRFWLVINQEG
NMVTARQEPRLVLISLTCDGDTLTLSAMNIFEMLRIDEGLRLKIYKDTEG
YYTIGIGHLLTKSPSLNAAKSELDKAIGRNCNGVITKDEAEKLFNQDVDA
AVRGILRNAKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTNSLRMLQQ
KRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYTKDLLLPIKTPT
TNAVHKCRVHGLEIEGRDCGEAAAQWITSFLKSQPYRLVHFEPHMRPRRP
HQIADLFRPKDQIAYSDTSPFLILSEASLADLNSRLEKKVKATNFRPNIV
ISGCDVYAEDSWDELLIGDVELKRVMACSRCILTTVDPDTGVMSRKEPLE
TLKSYRQCDPSERKLYGKSPLFGQYFVLENPGTIKVGDPVYLLG
Ligand information
Ligand IDMOO
InChIInChI=1S/Mo.4O/q;;;2*-1
InChIKeyMEFBJEMVZONFCJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-][Mo](=O)(=O)[O-]
ACDLabs 10.04
CACTVS 3.341		[O-][Mo]([O-])(=O)=O
FormulaMo O4
NameMOLYBDATE ION;
MOLYBDATE
ChEMBL
DrugBankDB15878
ZINC
PDB chain6fw2 Chain A Residue 1204 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6fw2 Crystal structure of human mARC1 reveals its exceptional position among eukaryotic molybdenum enzymes.
Resolution1.78 Å
Binding residue
(original residue number in PDB)		R1014 L1015 K1016
Binding residue
(residue number reindexed from 1)		R91 L92 K93
Annotation score4
Enzymatic activity
Enzyme Commision number 1.7.-.-
3.2.1.17: lysozyme.
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0003824 catalytic activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0030151 molybdenum ion binding
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6fw2, PDBe:6fw2, PDBj:6fw2
PDBsum6fw2
PubMed30397129
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E);
Q5VT66

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