Structure of PDB 6f7h Chain A Binding Site BS02

Receptor Information
>6f7h Chain A (length=251) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLLARQCLAEFLGVFVLMLLTQGAVAQAVTSGETKGNFFTMFLAGSLAVT
IAIYVGGNVSGAHLNPAFSLAMCIVGRLPWVKLPIYILVQLLSAFCASGA
TYVLYHDALQNYTGGNLTVTGPKETASIFATYPAPYLSLNNGFLDQVLGT
GMLIVGLLAILDRRNKGVPAGLEPVVVGMLILALGLSMGANCGIPLNPAR
DLGPRLFTYVAGWGPEVFSAGNGWWWVPVVAPLVGATVGTATYQLLVALH
H
Ligand information
Ligand IDGOL
InChIInChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
InChIKeyPEDCQBHIVMGVHV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C(C(CO)O)O
ACDLabs 12.01
CACTVS 3.370		OCC(O)CO
FormulaC3 H8 O3
NameGLYCEROL;
GLYCERIN;
PROPANE-1,2,3-TRIOL
ChEMBLCHEMBL692
DrugBankDB09462
ZINCZINC000000895048
PDB chain6f7h Chain A Residue 405 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6f7h Human adipose glycerol flux is regulated by a pH gate in AQP10.
Resolution2.304 Å
Binding residue
(original residue number in PDB)		S63 M196
Binding residue
(residue number reindexed from 1)		S46 M179
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015204 urea transmembrane transporter activity
GO:0015250 water channel activity
GO:0015254 glycerol channel activity
GO:0015267 channel activity
Biological Process
GO:0006833 water transport
GO:0009636 response to toxic substance
GO:0015791 polyol transmembrane transport
GO:0015793 glycerol transmembrane transport
GO:0051289 protein homotetramerization
GO:0055085 transmembrane transport
GO:0071468 cellular response to acidic pH
GO:0071918 urea transmembrane transport
Cellular Component
GO:0005811 lipid droplet
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6f7h, PDBe:6f7h, PDBj:6f7h
PDBsum6f7h
PubMed30420639
UniProtQ96PS8|AQP10_HUMAN Aquaporin-10 (Gene Name=AQP10)

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