Structure of PDB 6f6d Chain A Binding Site BS02

Receptor Information

>6f6d Chain A (length=450) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ESYLSPAQSVKPKINTEEKLPREKLNPPTPSIYLESKRDAFSPVLLQFCT
DPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVRTQVQQPSDEN
WDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESHIIKFGTNIDLSDAK
RWKPQLQELLKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTP
GHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDRHGVDYLTGSWW
PILDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNVGPL
TAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKF
CLLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYCNECDVEVFNILFV
TSENGSRNTYLVHCEGCARRRSAGLQGVVVLEQYRTEELAQAYDAFTLAP

Ligand information

Ligand ID

InChI

InChI=1S/Fe/q+3

InChIKey

VTLYFUHAOXGGBS-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 CACTVS 3.341 OpenEye OEToolkits 1.5.0	[Fe+3]

Formula

Name

FE (III) ION

PDB chain

6f6d Chain A Residue 1701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6f6d Structural Basis of Histone Demethylase KDM6B Histone 3 Lysine 27 Specificity.
Resolution	1.81811 Å
Binding residue (original residue number in PDB)	H1390 E1392 H1470
Binding residue (residue number reindexed from 1)	H202 E204 H282
Annotation score	1

Enzymatic activity

Enzyme Commision number

1.14.11.68: [histone H3]-trimethyl-L-lysine(27) demethylase.

External links

PDB	RCSB:6f6d, PDBe:6f6d, PDBj:6f6d
PDBsum	6f6d
PubMed	29220567
UniProt	O15054\|KDM6B_HUMAN Lysine-specific demethylase 6B (Gene Name=KDM6B)

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