Structure of PDB 6f5p Chain A Binding Site BS02

Receptor Information

>6f5p Chain A (length=708) Species: 100673 (Influenza C virus (C/Johannesburg/1/66))

MSKTFAEIAEAFLEPEAVRIAKEAVEEYGDHERKIIQIGIHFQVCCMFCD
EYLSTNGSDRFVLIEGRKRGTAVSLQNELCKSYDLEPLPFLCDIFDREEK
QFVEIGITRKADDSYFQSKFGKLGNSCKIFVFSYDGRLDKNCEGPMEEQK
LRIFSFLATAADFLRKENMFNEIFLPDNEETIIEMKKGKTFLELRDESVP
LPFQTYEQMKDYCEKFKGNPRELASKVSQMQSNIKLPIKHYEQNKFRQIR
LPKGPMAPYTHKFLMEEAWMFTKISDPERSRAGEILIDFFKKGNLSAIRP
KDKPLQGKYPIHYKNLWNQIKAAIADRTMVINENDHSEFLGGIGRASKKI
PEISLTQDVITTEGLKQSENKLPEPRSFPRWFNAEWMWAIKDSDLTGWVP
MAEYPPADNELEDYAEHLNKTMEGVLQGTNCAREMGKCILTVGALMTECR
LFPGKIKVVPIYARSKERKSMQEGLPVPSEMDCLFGICVKSKSHLNKDDG
MYTIITFEFSIREPNLEKHQKYTVFEAGHTTVRMKKGESVIGREVPLYLY
CRTTALSKIKNDWLSKARRCFITTMDTVETICLRESAKAEENLVEKTLNE
KQMWIGKKNGELIAQPLREALRVQLVQQFYFCIYNDSQLEGFCNEQKKIL
MALEGDKKNKSSFGFNPEGLLEKIEECLINNPMCLFMAQRLNELVIEASK
RGAKFFKT

Ligand information

>6f5p Chain H (length=10) Species: 9606 (Homo sapiens)

AAAAAAAAAA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6f5p A Mechanism for the Activation of the Influenza Virus Transcriptase.
• Resolution: 4.14 Å
• Binding residue (original residue number in PDB): W269 M270 F271 T272
• Binding residue (residue number reindexed from 1): W269 M270 F271 T272

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0039694 viral RNA genome replication
• GO:0075523 viral translational frameshifting
• GO:0075526 cap snatching

Cellular Component

• GO:0030430 host cell cytoplasm
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:6f5p, PDBe:6f5p, PDBj:6f5p
• PDBsum: 6f5p
• PubMed: 29910112
• UniProt: Q9IMP5|PA_INCJH Polymerase acidic protein (Gene Name=PA)