Structure of PDB 6f3f Chain A Binding Site BS02

Receptor Information

>6f3f Chain A (length=449) Species: 10090 (Mus musculus)

RMVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTG
YIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETT
KGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYY
SKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGE
VWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS
EEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERM
NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA
PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR
MPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQP

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6f3f Chain A Residue 602

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6f3f A switch in nucleotide affinity governs activation of the Src and Tec family kinases.
• Resolution: 2.41796 Å
• Binding residue (original residue number in PDB): N391 D404
• Binding residue (residue number reindexed from 1): N311 D324
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D386 A390 N391 D404
• Catalytic site (residue number reindexed from 1): D306 A310 N311 D324
• Enzyme Commision number: 2.7.10.2: non-specific protein-tyrosine kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004713 protein tyrosine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:6f3f, PDBe:6f3f, PDBj:6f3f
• PDBsum: 6f3f
• PubMed: 29234112
• UniProt: P05480|SRC_MOUSE Proto-oncogene tyrosine-protein kinase Src (Gene Name=Src)