Structure of PDB 6exf Chain A Binding Site BS02

Receptor Information
>6exf Chain A (length=343) Species: 239 (Flavobacterium sp.) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LEIPTSPLIIKITQQERNILSNVGNLLVKAFGNYENPDYIASLHLHAFQL
LPERITRILSQFGSDFSAEQYGAIVFQGLIEVDQDDLGPTPPNWQGADYG
KLNKYGFICSLLHGAVPSKPVQYYAQRKGGGLLHAVIPDEKMAATQTGSG
SKTDLFVHTEDAFLSNQADFLSFLYLRNEERVPSTLYSIRSHGKMNPVMK
KLFEPIYQCPKDSGPTASVLYGNRELPFIRFDAAEQIFNENAGQTSEALG
NLMDFWDEAKTLINSDYIPNSGDLIFVNNHLCAHGRSAFIAGQRIENGEI
IKCERRQMLRMMSKTSLIHIRSVTRTDDPYFIMEEHLGKIFDL
Ligand information
Ligand IDLYS
InChIInChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1
InChIKeyKDXKERNSBIXSRK-YFKPBYRVSA-O
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CCCC[NH3+])C(O)=O
ACDLabs 10.04O=C(O)C(N)CCCC[NH3+]
OpenEye OEToolkits 1.5.0C(CC[NH3+])C[C@@H](C(=O)O)N
CACTVS 3.341N[C@@H](CCCC[NH3+])C(O)=O
OpenEye OEToolkits 1.5.0C(CC[NH3+])CC(C(=O)O)N
FormulaC6 H15 N2 O2
NameLYSINE
ChEMBL
DrugBank
ZINC
PDB chain6exf Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6exf Structural Studies based on two Lysine Dioxygenases with Distinct Regioselectivity Brings Insights Into Enzyme Specificity within the Clavaminate Synthase-Like Family.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		V154 G166 Y193 S202 G313 R314 R334 M336
Binding residue
(residue number reindexed from 1)		V136 G148 Y175 S184 G285 R286 R306 M308
Annotation score5
Enzymatic activity
Enzyme Commision number 1.14.11.-
Gene Ontology
Molecular Function
GO:0016706 2-oxoglutarate-dependent dioxygenase activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity

View graph for
Molecular Function
External links
PDB RCSB:6exf, PDBe:6exf, PDBj:6exf
PDBsum6exf
PubMed30410048
UniProtJ3BZS6|LYS4O_FLASC L-lysine 4-hydroxylase (Gene Name=PMI10_03368)

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