Structure of PDB 6eu6 Chain A Binding Site BS02

Receptor Information

>6eu6 Chain A (length=405) Species: 174633 (Candidatus Kuenenia stuttgartiensis)

MENIQININHLWVIMAACMVFLMQLGFTSYETGFSQSKNAISIALRNLVD
TLISSLVFFSVGFGFMFGKSYMGLIGIDLFFANDLALHPNTLSYSFFFFQ
MVFASTAATILTGAIAERSGFIPNIAGTAFIVAIIYPIFGHWAWGNLFSP
DQTGWLKELGFIDFAGATVVHSIGGWFAMAAAIMVGPRIDKYNPDGSSNR
IGLHNVPLATLGTFFLWFGWFGFNGGSLLRVSVNIGLVILNTNMAAASAG
VSALIFIYATRKRIEAGSLFTAILAGLVAITASSNMVTPVSAVAIGLITG
ILAIIAEGFIEKTLKIDDPVSAIAVHGVGGVIGTLCVAIFAQKSYLLAEN
GSRMHQLGIQALGVIVAFSWSFGLGMLFFLCLKKVKRLRVTPEEEKRGLN
VAEAA

Ligand information

• Ligand ID: NH4
• InChI: InChI=1S/H3N/h1H3/p+1
• InChIKey: QGZKDVFQNNGYKY-UHFFFAOYSA-O
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [NH4+]
• Formula: H4 N
• Name: AMMONIUM ION
• PDB chain: 6eu6 Chain A Residue 505

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6eu6 Signaling ammonium across membranes through an ammonium sensor histidine kinase.
• Resolution: 1.98 Å
• Binding residue (original residue number in PDB): Q24 N47 D50 T51
• Binding residue (residue number reindexed from 1): Q24 N47 D50 T51
• Annotation score: 5

Enzymatic activity

• Enzyme Commision number: 2.7.13.3: histidine kinase.

Gene Ontology

Molecular Function

• GO:0008519 ammonium channel activity

Biological Process

• GO:0072488 ammonium transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:6eu6, PDBe:6eu6, PDBj:6eu6
• PDBsum: 6eu6
• PubMed: 29323112
• UniProt: Q1Q357