Structure of PDB 6esl Chain A Binding Site BS02

Receptor Information

>6esl Chain A (length=359) Species: 446 (Legionella pneumophila)

SPVHEQLQVPQCLAAKITVPHKILAENKEFKIIDVLSSDVETLTILADKV
SCGHFVNVSHKLQQQSAQKLLQGVSKLVYEIKHEEEVNAALKEIVSDNIW
QTLTHMTSYYNRSATKDTGVETANWLKSKFEQMAVEYGRTDTSTFFVKTG
WYKQPSLVTVIGKDIKAPAIVIGAHMDTLDGRMPGAGDDGSGSSSIMEAA
RVILSSKTTFKRPIYFIWYAAEERGLVGSQHVVQHFQEQSIPVKAVVQFD
MTGYRNDANDPTMWVFTDYTDRDLSNYLAKLIDHYIHVPVDYSRCGYGCS
DHASWNEEDIPAAFPCETSFADHNPYIHTSSDKMDLLNLEHMTNFSKLAV
AFAIELASE

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 6esl Chain A Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6esl Type II Secretion-Dependent Aminopeptidase LapA and Acyltransferase PlaC Are Redundant for Nutrient Acquisition duringLegionella pneumophilaIntracellular Infection of Amoebas.
• Resolution: 1.87 Å
• Binding residue (original residue number in PDB): H194 D207 D269
• Binding residue (residue number reindexed from 1): H175 D188 D250
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): H194 D207 E241 E242 D269 H347
• Catalytic site (residue number reindexed from 1): H175 D188 E222 E223 D250 H328
• Enzyme Commision number: 3.4.11.10: bacterial leucyl aminopeptidase.

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0008235 metalloexopeptidase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:6esl, PDBe:6esl, PDBj:6esl
• PDBsum: 6esl
• PubMed: 29666285
• UniProt: Q5ZRR6