Structure of PDB 6eem Chain A Binding Site BS02

Receptor Information
>6eem Chain A (length=487) Species: 3469 (Papaver somniferum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QNPLDPDEFRRQGHMIIDFLADYYKNVEKYPVRSQVEPGYLKKRLPESAP
YNPESIETILEDVTNDIIPGLTHWQSPNYFAYFPSSGSIAGFLGEMLSTG
FNVVGFNWMSSPAATELESIVMNWLGQMLTLPKSFLFSSDGGGGGVLQGT
TCEAILCTLTAARDKMLNKIGRENINKLVVYASDQTHCALQKAAQIAGIN
PKNVRAIKTSKATNFGLSPNSLQSAILADIESGLVPLFLCATVGTTSSTA
VDPIGPLCAVAKLYGIWVHIDAAYAGSACICPEFRHFIDGVEDADSFSLN
AHKWFFTTLDCCCLWVKDSDSLVKALSTSPEYLKNQVIDYKDWQIALSRR
FRSMKLWLVLRSYGVANLRTFLRSHVKMAKHFQGLIGMDNRFEIVVPRTF
AMVCFRLKPTAIFKQKIVDNDYIEDQTNEVNVKLLESVNASGKIYMTHAV
VGGVYMIRFAVGATLTEERHVTGAWKVVQEHTDAILG
Ligand information
Ligand IDTYR
InChIInChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1
InChIKeyOUYCCCASQSFEME-QMMMGPOBSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(N)Cc1ccc(O)cc1
OpenEye OEToolkits 1.5.0c1cc(ccc1C[C@@H](C(=O)O)N)O
OpenEye OEToolkits 1.5.0c1cc(ccc1CC(C(=O)O)N)O
CACTVS 3.341N[CH](Cc1ccc(O)cc1)C(O)=O
CACTVS 3.341N[C@@H](Cc1ccc(O)cc1)C(O)=O
FormulaC9 H11 N O3
NameTYROSINE
ChEMBLCHEMBL925
DrugBankDB00135
ZINCZINC000000266964
PDB chain6eem Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6eem Structural basis for divergent and convergent evolution of catalytic machineries in plant aromatic amino acid decarboxylase proteins.
Resolution2.61001 Å
Binding residue
(original residue number in PDB)		Y350 L371
Binding residue
(residue number reindexed from 1)		Y332 L347
Annotation score5
Enzymatic activity
Enzyme Commision number 4.1.1.25: tyrosine decarboxylase.
Gene Ontology
Molecular Function
GO:0004837 tyrosine decarboxylase activity
GO:0016830 carbon-carbon lyase activity
GO:0016831 carboxy-lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006520 amino acid metabolic process
GO:0019752 carboxylic acid metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6eem, PDBe:6eem, PDBj:6eem
PDBsum6eem
PubMed32371491
UniProtO82415|TYDC_PAPSO Tyrosine decarboxylase (Gene Name=TYDC)

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