Structure of PDB 6edc Chain A Binding Site BS02
Receptor Information
>6edc Chain A (length=347) Species:
9606
(Homo sapiens) [
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GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLN
TGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKNPLSQF
LEGEILSASKMLSKFRKIIKEEINDIDVIMEAERGGSPAVTLLISEKISV
DITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAQEET
WRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERF
KDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQC
LRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDE
Ligand information
>6edc Chain C (length=15) [
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ttcgtcttcggcaat
Receptor-Ligand Complex Structure
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PDB
6edc
Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation.
Resolution
2.712 Å
Binding residue
(original residue number in PDB)
S180 A183 N210 Y214 Y215 K384 K400
Binding residue
(residue number reindexed from 1)
S20 A23 N50 Y54 Y55 K210 K226
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:6edc
,
PDBe:6edc
,
PDBj:6edc
PDBsum
6edc
PubMed
31142647
UniProt
Q8N884
|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)
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