Structure of PDB 6edb Chain A Binding Site BS02
Receptor Information
>6edb Chain A (length=357) Species:
9606
(Homo sapiens) [
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KLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGS
YYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENPLS
QFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLIS
EKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKH
AKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLM
KYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLC
FDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERN
NEFPVFD
Ligand information
>6edb Chain D (length=21) [
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gcattgtttagatcccggatc
Receptor-Ligand Complex Structure
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PDB
6edb
Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation.
Resolution
3.209 Å
Binding residue
(original residue number in PDB)
R176 Y214 Y215 K400
Binding residue
(residue number reindexed from 1)
R13 Y51 Y52 K237
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:6edb
,
PDBe:6edb
,
PDBj:6edb
PDBsum
6edb
PubMed
31142647
UniProt
Q05066
|SRY_HUMAN Sex-determining region Y protein (Gene Name=SRY);
Q8N884
|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)
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