Structure of PDB 6eb5 Chain A Binding Site BS02

Receptor Information
>6eb5 Chain A (length=228) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATGPNGQIEYVIQYNPDD
PTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRTTTTLTVDVL
DGDDLGPMFLPCVLNDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD
RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
FDLVIKAEQDNGHPLPAFAGLHIEILDE
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6eb5 Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6eb5 Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		D238 L240 D287 D289 Q348
Binding residue
(residue number reindexed from 1)		D103 L105 D148 D150 Q209
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6eb5, PDBe:6eb5, PDBj:6eb5
PDBsum6eb5
PubMed32963095
UniProtQ96QU1|PCD15_HUMAN Protocadherin-15 (Gene Name=PCDH15)

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