Structure of PDB 6dvz Chain A Binding Site BS02

Receptor Information
>6dvz Chain A (length=643) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKKRLKKRIFAAVSEGCVEELRELLQDLQDLCRRRRGLDVPDFLMHKLTA
SDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILDRFINAEYTEEAYE
GQTALNIAIERRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGET
PLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQN
DFVKRMYDMILLRSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILSRE
IKEKPLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEIIVYNTNID
NRHEMLTLEPLHTLLHTKWKKFAKYMFFLSFCFYFFYNITLTLVSYYRPR
EDEDLPHPLALTHKMSWLQLLGRMFVLIWATCISVKEGIAIFLLRPSDLQ
SILSDAWFHFVFFVQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLA
YTRGFQSMGMYSVMIQKVILHDVLKFLFVYILFLLGFGVALASLIEKCSK
DKKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSTYPILFLFLLITYVIL
TFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSR
FRMGELCKVADEDFRLCLRINEVKWTEWKTHVSFLNEDPGPIR
Ligand information
Ligand IDFZ4
InChIInChI=1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2
InChIKeyBLZVCIGGICSWIG-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01
OpenEye OEToolkits 2.0.6		B(c1ccccc1)(c2ccccc2)OCCN
CACTVS 3.385NCCOB(c1ccccc1)c2ccccc2
FormulaC14 H16 B N O
Name2-aminoethyl diphenylborinate
ChEMBLCHEMBL169233
DrugBank
ZINCZINC000169743034
PDB chain6dvz Chain A Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6dvz Structure and gating mechanism of the transient receptor potential channel TRPV3.
Resolution4.24 Å
Binding residue
(original residue number in PDB)		S444 W493 K500 E501 F526 Y565
Binding residue
(residue number reindexed from 1)		S330 W379 K386 E387 F412 Y451
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0009266 response to temperature stimulus
GO:0042636 negative regulation of hair cycle
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0090280 positive regulation of calcium ion import
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043235 receptor complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6dvz, PDBe:6dvz, PDBj:6dvz
PDBsum6dvz
PubMed30127359
UniProtQ8K424|TRPV3_MOUSE Transient receptor potential cation channel subfamily V member 3 (Gene Name=Trpv3)

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