Structure of PDB 6dno Chain A Binding Site BS02

Receptor Information
>6dno Chain A (length=294) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELE
APLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICL
LLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCF
NCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLW
SDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYE
FFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6dno Identification of the substrate recruitment mechanism of the muscle glycogen protein phosphatase 1 holoenzyme.
Resolution1.45 Å
Binding residue
(original residue number in PDB)		R96 H125 Y134 D197 W206 D220 R221 Y272 C273 E275
Binding residue
(residue number reindexed from 1)		R90 H119 Y128 D191 W200 D214 R215 Y266 C267 E269
Enzymatic activity
Catalytic site (original residue number in PDB) D64 H66 D92 D95 R96 N124 H125 H173 R221 H248
Catalytic site (residue number reindexed from 1) D58 H60 D86 D89 R90 N118 H119 H167 R215 H242
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:6dno, PDBe:6dno, PDBj:6dno
PDBsum6dno
PubMed30443599
UniProtP62136|PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (Gene Name=PPP1CA)

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