Structure of PDB 6d6v Chain A Binding Site BS02

Receptor Information
>6d6v Chain A (length=980) Species: 5911 (Tetrahymena thermophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QMLTRKEDLLTVLKQISALKYVSNLYEFLLATEKIVQTSELDTQFQEFLT
TTIIASEQNLVENYKQKYNQPNFSQLTIKQVIDDSIILLGNKQNYVQQIG
TTTIGFYVEYENINLSRQTLYSSNFRNLLNIFGEEDFKYFLIDFLVFTKV
EQNGYLQVAGVCLNQYFSVQKQENQYIYPEIQRSQIFYCNHMGREPGVFK
SSFFNYQSKNFSCQEERDLFLEFTEKIVQNFHNINFNYLLKKFCKLPENY
QSLKSQVKQIVQSENKANQQSCENLFNSLYDTEISYKQITNFLRQIIQNC
VPNQLLGKKNFKVFLEKLYEFVQMKRFENQKVLDYICFMDVFDVEWFVDL
KNQKFTQKRKYISDKRKILGDLIVFIINKIVIPVLRYNFYITEKHKEGSQ
IFYYRKPIWKLVSKLTIVKLEEFQKYPQGKLRIIPKKGSFRPIMTFLRKD
KQKNIKLNLNQILMDSQLVFRNLKDMLGQKIGYSVFDNKQISEKFAQFIE
KWKNKGRPQLYYVTLDIKKCYDSIDQMKLLNFFNQSDLIQDTYFINKYLL
FQRNKRPLLQIQNFPYYFNLKERQIAYSLYDDDDQILQKGFKEIQSDDRP
FIVINQDKPRCITKDIIHNHLKHISQYNVISFNKVKFRQKRGIPQGLNIS
GVLCSFYFGKLEEEYTQFLKNAEQVNGSINLLMRLTDDYLFISDSQQNAL
NLIVQLQNCANNNGFMFNDQKITTNFQFPQEDYNLEHFKISVQNECQWIG
KSIDMNTLEIKSIQKQTQQEINQTINVAISIKNLKSQLKNKLRSLFLNQL
IDYFNPNINSFEGLCRQLYHHSKATVMKFYPFMTKLFQIDLKKSKQYSVQ
YGKENTNENFLKDILYYTVEDVCKILCYLQFEDEINSNIKEIFKNLYSWI
MWDIIVSYLKKKKQFKGYLNKLLQKIRKSRFFYLKEGCKSLQLILSQQKY
QLNKKELEAIEFIDLNNLIQDIKTLIPKIS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6d6v Structure of Telomerase with Telomeric DNA.
Resolution4.8 Å
Binding residue
(original residue number in PDB)		Q228 F414 H482 I545 K555 Y623 Q773 D815 D816 I877 G878 T902 N904 K919 S922 F924 L925 F960
Binding residue
(residue number reindexed from 1)		Q185 F327 H395 I443 K453 Y521 Q645 D687 D688 I749 G750 T774 N776 K791 S794 F796 L797 F832
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003720 telomerase activity
GO:0003723 RNA binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0042162 telomeric DNA binding
GO:0046872 metal ion binding
GO:0070034 telomerase RNA binding
Biological Process
GO:0007004 telomere maintenance via telomerase
Cellular Component
GO:0000333 telomerase catalytic core complex
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005697 telomerase holoenzyme complex
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6d6v, PDBe:6d6v, PDBj:6d6v
PDBsum6d6v
PubMed29775593
UniProtO77448|TERT_TETTS Telomerase reverse transcriptase (Gene Name=TERT)

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