Structure of PDB 6d3k Chain A Binding Site BS02

Receptor Information

>6d3k Chain A (length=258) Species: 9606 (Homo sapiens)

KYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKA
EREVKALAKLDHVNIVHYNGCWDGFDYDPRSKTKCLFIQMEFCDKGTLEQ
WIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTK
QVKIGDFGLVTSLKTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCD
TAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTL
TVWKKSPE

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6d3k Chain A Residue 603

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6d3k Structural Basis of Protein Kinase R Autophosphorylation.
• Resolution: 2.6 Å
• Binding residue (original residue number in PDB): N419 D432
• Binding residue (residue number reindexed from 1): N143 D156
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D414 K416 S418 N419 D432 T451
• Catalytic site (residue number reindexed from 1): D138 K140 S142 N143 D156 T165
• Enzyme Commision number: 2.7.10.2: non-specific protein-tyrosine kinase.
  2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:6d3k, PDBe:6d3k, PDBj:6d3k
• PDBsum: 6d3k
• PubMed: 31246429
• UniProt: P19525|E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase (Gene Name=EIF2AK2)