Structure of PDB 6d06 Chain A Binding Site BS02

Receptor Information
>6d06 Chain A (length=384) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKDA
KVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLN
NKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILEE
PADRHPNRKARGQLRTKIESGYGTIPVRSNASIQTWDGVLQGERLLTMSC
SDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISN
IEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINATT
GKDELGRASRLCKHALYCRWMRVHGKVPSHLLRSKITKPNVYHESKLAAK
EYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSLT
Ligand information
>6d06 Chain C (length=23) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cagagcccccuagcaucgcgagc
.......................
Receptor-Ligand Complex Structure
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PDB6d06 A Bump-Hole Approach for Directed RNA Editing.
Resolution2.55 Å
Binding residue
(original residue number in PDB)		R348 I456 F457 R470 H471 R474 A476 R477 R481 Y488 I491 P492 S495 R510 K594
Binding residue
(residue number reindexed from 1)		R32 I140 F141 R154 H155 R158 A160 R161 R165 Y172 I175 P176 S179 R194 K278
Enzymatic activity
Enzyme Commision number 3.5.4.37: double-stranded RNA adenine deaminase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004000 adenosine deaminase activity
Biological Process
GO:0006396 RNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:6d06, PDBe:6d06, PDBj:6d06
PDBsum6d06
PubMed30581135
UniProtP78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)

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