Structure of PDB 6cxo Chain A Binding Site BS02

Receptor Information
>6cxo Chain A (length=465) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PIPIDCRMSPWSEWSECDPCLKQRFRSRSILAFGQFNGKSCVDVLGDRQG
CEPTQECEEIQENCGNDFQCETGRCIKRRLLCNGDNDCGDYSDENDCDDD
PRTPCRDRVAEESELGLTAGYGINILGMEPLRTPFDNEFYNGLCDRVRDE
KTYYRKPWNVVSLIYETKADKSFRTENYDEHLEVFKAINREKTSNFNADF
ALKFSATEVPEFKFSYFMGKNFRRLSSYFSQSKKMFVHLRGVVQLGRFVM
RNRDVVLRSTFLDDVKALPTSYEKGEYFGFLETYGTHYSTSGSLGGQYEI
VYVLDKASMKEKGVDLNDVKHCLGFNMDLGCIKTVDITRDNIIDDVISFI
RGGTREQAILLKEKILRGDKTFDKTDFANWASSLANAPALISQRMSPIYN
LIPLKIKDAYIKKQNLEKAVEDYIDEFSTKRCYPCLNGGTIILLDGQCLC
SCPMMFRGMACEIHQ
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6cxo Chain A Residue 604 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6cxo The first transmembrane region of complement component-9 acts as a brake on its self-assembly.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		S209 N212 D214
Binding residue
(residue number reindexed from 1)		S194 N197 D199
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0001906 cell killing
GO:0006955 immune response
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0031640 killing of cells of another organism
GO:0050778 positive regulation of immune response
GO:0051260 protein homooligomerization
Cellular Component
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0044218 other organism cell membrane

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6cxo, PDBe:6cxo, PDBj:6cxo
PDBsum6cxo
PubMed30111885
UniProtP06683|CO9_MOUSE Complement component C9 (Gene Name=C9)

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