Structure of PDB 6cvo Chain A Binding Site BS02

Receptor Information
>6cvo Chain A (length=175) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKARYHWLVLPWTSISSLK
AVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRLGYHAIPSMSHVHLHVI
SQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMPELLK
LPLRCHECQQLLPSIPQLKEHLRKH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6cvo Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		H166 W167 K276 S328 I329 P330
Binding residue
(residue number reindexed from 1)		H2 W3 K112 S164 I165 P166
Enzymatic activity
Enzyme Commision number 3.6.1.71: adenosine-5'-diphospho-5'-[DNA] diphosphatase.
3.6.1.72: DNA-3'-diphospho-5'-guanosine diphosphatase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:6cvo, PDBe:6cvo, PDBj:6cvo
PDBsum6cvo
PubMed29934293
UniProtQ7Z2E3|APTX_HUMAN Aprataxin (Gene Name=APTX)

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