Structure of PDB 6cta Chain A Binding Site BS02
Receptor Information
>6cta Chain A (length=344) Species:
9606
(Homo sapiens) [
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GASKLRAVLEKLKLSRDDISTAAGMVNGVVDHLLRRLKCDSAFRGVGLLN
TGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKNPLSQF
LEGEILSASKMLSKFRKIIKEEINDIDVIMKGGSPAVTLLISEKISVDIT
LALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAQEETWRL
SFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDK
KHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRT
EKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDE
Ligand information
>6cta Chain C (length=16) [
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aaattgccgaagacga
Receptor-Ligand Complex Structure
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PDB
6cta
Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.
Resolution
2.779 Å
Binding residue
(original residue number in PDB)
K173 L174 S175 R176 K198 H217 K407
Binding residue
(residue number reindexed from 1)
K13 L14 S15 R16 K38 H57 K230
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:6cta
,
PDBe:6cta
,
PDBj:6cta
PDBsum
6cta
PubMed
30007416
UniProt
Q8N884
|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)
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