Structure of PDB 6cst Chain A Binding Site BS02

Receptor Information
>6cst Chain A (length=446) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIE
NMMQQKAQITSQQLRKAQLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAV
EMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLI
IVPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEERQNWP
EDKRRYFIKNSVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKV
CSDKNKPNGQYQILPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIIT
CTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVERTF
SEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRAS
TVSSVVSTAEEIFAIAKELLKTEIDADFPHPLRLRLMGVRISSFPN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6cst 2.0 angstrom resolution crystal structure of human pol kappa reveals a new catalytic function of N-clasp in DNA replication.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		T44 F49 M133 S134 M135 P153 F155 I156 S388 S391 R413 K414 S415 M416 S417 V418 E419 R420 T421 R507
Binding residue
(residue number reindexed from 1)		T29 F34 M118 S119 M120 P138 F140 I141 S316 S319 R341 K342 S343 M344 S345 V346 E347 R348 T349 R435
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6cst, PDBe:6cst, PDBj:6cst
PDBsum6cst
PubMed30310122
UniProtQ9UBT6|POLK_HUMAN DNA polymerase kappa (Gene Name=POLK)

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