Structure of PDB 6cnf Chain A Binding Site BS02

Receptor Information
>6cnf Chain A (length=1428) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEVVVSETPKRIKGLEFSALSAADIVAQSEVEVSTRDLFDLEKDRAPKAN
GALDPKMGVSSSSLECATCHGNLASCHGHFGHLKLALPVFHIGYFKATIQ
ILQGICKNCSAILLSETDKRQFLHELRRPGVDNLRRMGILKKILDQCKKQ
RRCLHCGALNGVVKKAAAGAGSAALKIIHDTFRWVGKKSAPEKDIWVGEW
KEVLAHNPELERYVKRCMDDLNPLKTLNLFKQIKSADCELLGIDATVPSG
RPETYIWRYLPAPPVCIRPSVMMQDSPASNEDDLTVKLTEIVWTSSLIKA
GLDKGISINNMMEHWDYLQLTVAMYINSDSVNPAMLPGSSNGGGKVKPIR
GFCQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLSIDEVAVPDRVAKV
LTYPEKVTRYNRHKLQELIVNGPNVHPGANYLLKRNEDARRNLRYGDRMK
LAKNLQIGDVVERHLEDGDVVLFNRQPSLHRLSILSHYAKIRPWRTFRLN
ECVCTPYNADFDGDEMNLHVPQTEEARAEAINLMGVKNNLLTPKSGEPII
AATQDFITGSYLISHKDSFYDRATLTQLLSMMSDGIEHFDIPPPAIMKPY
YLWTGKQVFSLLIKPNHNSPVVINLDAKNKVFVPPKSKSLPNEMSQNDGF
VIIRGSQILSGVMDKSVLGDGKKHSVFYTILRDYGPQEAANAMNRMAKLC
ARFLGNRGFSIGINDVTPADDLKQKKEELVEIAYHKCDELITLFNKGELE
TQPGCNEEQTLEAKIGGLLSKVREEVGDVCINELDNWNAPLIMATCGSKG
STLNVSQMVAVVGQQIISGNRVPDGFQDRSLPHFPKNSKTPQSKGFVRNS
FFSGLSPPEFLFHAISGREGLVDTAVKTAETGYMSRRLMKSLEDLSCQYD
NTVRTSANGIVQFTYGGDGLDPLEMEGNAQPVNFNRSWDHAYNITFNNQD
KGLLPYAIMETANEILGPLEERLVRYDNSGCLVKREDLNKAEYVDQYDAE
RDFYHSLREYINGKATALANLRKSRGMLGLLEPPAKELQGIDPDETVPDN
VKTSVSQLYRISEKSVRKFLEIALFKYRKARLEPGTAIGAIGAQSIGEPM
NVTLGVPRIKEIINASKVISTPIINAVLVNDNDERAARVVKGRVEKTLLS
DVAFYVQDVYKDNLSFIQVRIDLGTIDKLQLELTIEDIAVAITRASKLKI
QASDVNIIGKDRIAINVFPSENDVFYRMQQLRRALPDVVVKGLPDISRAV
INIRDDGKRELLVEGYGLRDVMCTDGVIGSRTTTNHVLEVFSVLGIEAAR
YSIIREINYTMSNHGMSVDPRHIQLLGDVMTYKGEVLGITRFGLSKMRDS
VLQLASFEKTTDHLFDAAFYMKKDAVEGVSECIILGQTMSIGTGSFKVVK
GTNISEKDLVPKRCLFESLSNEAALKAN
Ligand information
>6cnf Chain Y (length=57) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
acgccttaaccaacttggccatggagtacagaaaaagtattactaatata
tgttgaa
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6cnf Structural visualization of RNA polymerase III transcription machineries.
Resolution4.5 Å
Binding residue
(original residue number in PDB)		V186 S340 N342 K358 K360 R372 A880 Y884 E1390 K1391
Binding residue
(residue number reindexed from 1)		V185 S339 N341 K357 K359 R371 A879 Y883 E1358 K1359
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation at RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0042797 tRNA transcription by RNA polymerase III
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6cnf, PDBe:6cnf, PDBj:6cnf
PDBsum6cnf
PubMed30083386
UniProtP04051|RPC1_YEAST DNA-directed RNA polymerase III subunit RPC1 (Gene Name=RPO31)

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