Structure of PDB 6cn2 Chain A Binding Site BS02

Receptor Information
>6cn2 Chain A (length=300) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TSSALKGAIQLGITHSVGSLSQKPERDVLMQDFEVVESIFFPSQGSSSTP
GHHHGDFKFKTYAPIAFRYFREMFGIRPDDYLYSLCNEPLIELSSLFYVS
SDDEFIIKTVQHKEAEFLQTLLPGYFMNLNQNMRTLLPKFYGLYCVQADG
KNIRIVVMNNLLPRAVPMHLKFNLKGSTYKRRASPKERSKGVPTYKDLDF
MQDMPEGILLENDHYTALSRTMQRDCRVLQSFKIMDYSLLVGIHILHMGG
IPAFNSKGERLLVFIGIIDILQSYRTVSVHRPSFYADRFQKFMCSTVFRK
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6cn2 Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6cn2 Structural insights into lethal contractural syndrome type 3 (LCCS3) caused by a missense mutation of PIP5K gamma.
Resolution3.102 Å
Binding residue
(original residue number in PDB)		K238 D378
Binding residue
(residue number reindexed from 1)		K175 D269
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.1.68: 1-phosphatidylinositol-4-phosphate 5-kinase.
Gene Ontology
Molecular Function
GO:0052742 phosphatidylinositol kinase activity
Biological Process
GO:0046488 phosphatidylinositol metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6cn2, PDBe:6cn2, PDBj:6cn2
PDBsum6cn2
PubMed29959184
UniProtQ503I3

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