Structure of PDB 6cja Chain A Binding Site BS02

Receptor Information
>6cja Chain A (length=381) Species: 272624 (Legionella pneumophila subsp. pneumophila str. Philadelphia 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KTHFDTRAIHAGQEPCKSTGAVMTPIYATSTYKQIAPGEHLGYEYSRTQN
PTRKAYEDCIASLESGQKGFAFASGMAAINTVIDLLGSGDHVVAMDDLYG
GTFRLFDKVKTRTSNLSFSFIDMSVPENIEAAITPKTKLLWLETPSNPML
KLANLRKIAAIAKKYNLITVADNTFATPWIQRPLELGFDIVLHSATKYLN
GHSDVVSGVVVVGDNSVLSDKIAFLQNSCGAVAGPFDSFLVLRSLKTLSV
RMQRHCENANHLANWLSSHPKIEKVIYPGLKSHPQYSLAKEQMNNFGGMI
SLVLKGSLEDAKRFLARCELFTLAESLGGVESLIEHPAIMTHASIPVEQR
KALGIEDGFIRLSVGIEHIDDLRADLEHALG
Ligand information
Ligand IDSER
InChIInChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKeyMTCFGRXMJLQNBG-REOHCLBHSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CO)C(O)=O
OpenEye OEToolkits 1.5.0C(C(C(=O)O)N)O
CACTVS 3.341N[C@@H](CO)C(O)=O
ACDLabs 10.04O=C(O)C(N)CO
OpenEye OEToolkits 1.5.0C([C@@H](C(=O)O)N)O
FormulaC3 H7 N O3
NameSERINE
ChEMBLCHEMBL11298
DrugBankDB00133
ZINCZINC000000895034
PDB chain6cja Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6cja Crystal structure of Cystathionine beta-lyase from Legionella pneumophila Philadelphia 1 in complex with Alanyl-PLP and Serine
Resolution1.7 Å
Binding residue
(original residue number in PDB)		R106 E327
Binding residue
(residue number reindexed from 1)		R104 E325
Annotation score2
Enzymatic activity
Enzyme Commision number 4.4.1.8: Transferred entry: 4.4.1.13.
Gene Ontology
Molecular Function
GO:0003962 cystathionine gamma-synthase activity
GO:0016829 lyase activity
GO:0016846 carbon-sulfur lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0019346 transsulfuration
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6cja, PDBe:6cja, PDBj:6cja
PDBsum6cja
PubMed
UniProtQ5ZX43

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