Structure of PDB 6bwy Chain A Binding Site BS02

Receptor Information

>6bwy Chain A (length=344) Species: 9606,284812

QLNELLNAGEYKIGELTFQSIRSSQELQKKNTIVNLFGIVKDFTPSRQSL
HGTKDWVTTVYLWDPTCDTSSIGLQIHLFSKQGNDLPVIKQVGQPLLLHQ
ITLRSYRDRTQGLSKDQFRYALWPDFSSNSKDTLCPQPMPRLMKTGDKEE
QFALLLNKIWDEQTNHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHN
DTWVKLNQRRGFLANQAPRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSP
CFSCAQEMAKFISKNKHVSLCIKTARIYDDQGRAQEGLRTLAEAGAKISI
MTYSEFKHCWDTFVDHQGAPFQPWDGLDEHSQDLSGRLRAILQN

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 6bwy Chain A Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6bwy Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): H257 C288 C291
• Binding residue (residue number reindexed from 1): H220 C251 C254
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.5.4.-
  3.5.4.38: single-stranded DNA cytosine deaminase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003824 catalytic activity
• GO:0008270 zinc ion binding
• GO:0016787 hydrolase activity

Biological Process

• GO:0000723 telomere maintenance

Cellular Component

• GO:0000781 chromosome, telomeric region

External links

• PDB: RCSB:6bwy, PDBe:6bwy, PDBj:6bwy
• PDBsum: 6bwy
• PubMed: 29596531
• UniProt: O13988|POT1_SCHPO Protection of telomeres protein 1 (Gene Name=pot1);
  Q9HC16|ABC3G_HUMAN DNA dC->dU-editing enzyme APOBEC-3G (Gene Name=APOBEC3G)