Structure of PDB 6bs1 Chain A Binding Site BS02

Receptor Information
>6bs1 Chain A (length=432) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQL
RKAQLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMRDNPELKDKPIA
VGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSK
EVKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDKRRYFIKNSVVF
GTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQIL
PNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLL
FSETSWHYFLHISLGLGSTHLTRDGERKSMSVERTFSEINKAEEQYSLCQ
ELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFA
IAKELLKTEIDADFPHPLRLRLMGVRISSFPN
Ligand information
Receptor-Ligand Complex Structure
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PDB6bs1 Structural Basis for Human DNA Polymerase Kappa to Bypass Cisplatin Intrastrand Cross-Link (Pt-GG) Lesion as an Efficient and Accurate Extender.
Resolution3.15 Å
Binding residue
(original residue number in PDB)		T44 F49 M133 S134 M135 A151 P153 F155 I156 S388 S391 R413 K414 S415 S417 V418 E419 R420 T421 R507
Binding residue
(residue number reindexed from 1)		T15 F20 M104 S105 M106 A122 P124 F126 I127 S302 S305 R327 K328 S329 S331 V332 E333 R334 T335 R421
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6bs1, PDBe:6bs1, PDBj:6bs1
PDBsum6bs1
PubMed29715472
UniProtQ9UBT6|POLK_HUMAN DNA polymerase kappa (Gene Name=POLK)

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