Structure of PDB 6brx Chain A Binding Site BS02

Receptor Information
>6brx Chain A (length=433) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQ
LRKAQLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMRDNPELKDKPI
AVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVS
KEVKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDKRRYFIKNSVV
FGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQI
LPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSL
LFSETSWHYFLHISLGLGSTHLTRDGERKSMSVERTFSEINKAEEQYSLC
QELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIF
AIAKELLKTEIDADFPHPLRLRLMGVRISSFPN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6brx Structural Basis for Human DNA Polymerase Kappa to Bypass Cisplatin Intrastrand Cross-Link (Pt-GG) Lesion as an Efficient and Accurate Extender.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		T44 F49 M133 S134 M135 P153 F155 I156 S388 T390 R413 K414 S415 M416 S417 V418 E419 T421 R507
Binding residue
(residue number reindexed from 1)		T16 F21 M105 S106 M107 P125 F127 I128 S303 T305 R328 K329 S330 M331 S332 V333 E334 T336 R422
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6brx, PDBe:6brx, PDBj:6brx
PDBsum6brx
PubMed29715472
UniProtQ9UBT6|POLK_HUMAN DNA polymerase kappa (Gene Name=POLK)

[Back to BioLiP]