Structure of PDB 6bkg Chain A Binding Site BS02

Receptor Information
>6bkg Chain A (length=600) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKN
DVTDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALK
LLNYRTPTGDAGDFAMIAYFVLKPRCQKGSLTIQQVNDLLDSIASNNSAK
RKDLIKKSLLQLITQSSALEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAA
ELHNVTTDLEKVCRQLHDPSVGLSDISITLFSAFKPMLAAIADIEHIEKD
MKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTDQFGASPTEGSLT
PFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMDLQTCYCV
FDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVID
ALNEAIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILI
VGGYWGKGSRGGMMSHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELY
DLGLKLAKYWKPFHRKAPPSSILCGTEKPEVYIEPCNSVIVQIKAAEIVP
SDMYKTGCTLRFPRIEKIRDDKEWHECMTLDDLEQLRGKASGKLASKHLY
Ligand information
Receptor-Ligand Complex Structure
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PDB6bkg Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis.
Resolution2.402 Å
Binding residue
(original residue number in PDB)		Q74 K162 Q200 Q201 F349 K473 R476 S481 H482 R505 V506 S567 Y570 L576 F578 P579
Binding residue
(residue number reindexed from 1)		Q66 K150 Q188 Q189 F337 K457 R460 S465 H466 R489 V490 S551 Y554 L560 F562 P563
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0051103 DNA ligation involved in DNA repair
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6bkg, PDBe:6bkg, PDBj:6bkg
PDBsum6bkg
PubMed29980672
UniProtP49917|DNLI4_HUMAN DNA ligase 4 (Gene Name=LIG4)

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