Structure of PDB 6bkf Chain A Binding Site BS02

Receptor Information
>6bkf Chain A (length=562) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKDVT
DSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLN
YRDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSL
LQLITQSSALEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDL
EKVCRQLHDPSVGLSDISITLFSAFKPMLAAIADIEHIEKDMKHQSFYIE
TKLDGERMQMHKDGDVYKYFSRNGYNYTDQFGASPTEGSLTPFIHNAFKA
DIQICILDGEMMAYNPNTQTFMQLQTCYCVFDVLMVNNKKLGHETLRKRY
EILSSIFTPIPGRIEIVQKTQAHTKNEVIDALNEAIDKREEGIMVKQPLS
IYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKRGGMMSHFLCAVA
EKPPKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILCG
TEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTLRFPRIEKIRDDKEWH
ECMTLDDLEQLR
Ligand information
Receptor-Ligand Complex Structure
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PDB6bkf Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis.
Resolution3.25 Å
Binding residue
(original residue number in PDB)		R293 R443 K449 K451
Binding residue
(residue number reindexed from 1)		R272 R407 K413 K415
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0051103 DNA ligation involved in DNA repair
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6bkf, PDBe:6bkf, PDBj:6bkf
PDBsum6bkf
PubMed29980672
UniProtP49917|DNLI4_HUMAN DNA ligase 4 (Gene Name=LIG4)

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