Structure of PDB 6b9d Chain A Binding Site BS02

Receptor Information
>6b9d Chain A (length=379) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKKAGPVQVLIVKDDHSFELDETALNRILLSEAVRDKEVVAVSVAGAFAK
GKSFLMDFMLRYMYNQESVDWVGNEPLTGFSTTGIQIWSEIFLINKPDGK
KVAVLLMDTQSATVFALSTMISSIQVYNLSQNVQEDDLQHLQLFTEYGRL
AMEETFLKPFQSLIFLVRDWSFPYEFSYGADGGAKFLEKRLKVSQHEELQ
NVRKHIHSCFTNISCFLLPHPGLKVATNPNFDGKLKEIDDEFIKNLKILI
PWLLSPESLDIKEINGNKITCRGLVEYFKAYIKIYLPHPKSMLQATAEAN
NLAAVATAKDTYNKKMEEICGFLAPNDLQTKHLQLKEESVKLFRGVKKMG
GEEFSRRYLQQLESEIDELYIQYIKHNDS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6b9d Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6b9d A hereditary spastic paraplegia-associated atlastin variant exhibits defective allosteric coupling in the catalytic core.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		K80 D146 Q148
Binding residue
(residue number reindexed from 1)		K52 D108 Q110
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.-
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:6b9d, PDBe:6b9d, PDBj:6b9d
PDBsum6b9d
PubMed29180453
UniProtQ8WXF7|ATLA1_HUMAN Atlastin-1 (Gene Name=ATL1)

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