Structure of PDB 6b7h Chain A Binding Site BS02

Receptor Information
>6b7h Chain A (length=441) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RREIKIGDLVLGGLFPINEKEECGRINEDRGIQRLEAMLFAIDEINKDDY
LLPGVKLGVHILDTCSRDTYALEQSLEFVRASLPLLIAGVIGGSYSSVSI
QVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEIL
RFFNWTYVSTVASEGDYGETGIEAFEQEARLRNISIATAEKVGRSNIRKS
YDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGA
QESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFW
EQKFQCSLRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLC
PNTTKLCDAMKILDGKKLYKDYLLKINFTAPDADSIVKFDTFGDGMGRYN
VFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSE
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6b7h Chain A Residue 807 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6b7h Synthesis and Pharmacological Characterization of C4beta-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3Receptor Agonist.
Resolution2.82 Å
Binding residue
(original residue number in PDB)		I79 N80 L86 P87
Binding residue
(residue number reindexed from 1)		I45 N46 L52 P53
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6b7h, PDBe:6b7h, PDBj:6b7h
PDBsum6b7h
PubMed29350927
UniProtQ14832|GRM3_HUMAN Metabotropic glutamate receptor 3 (Gene Name=GRM3)

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