Structure of PDB 6az3 Chain A Binding Site BS02

Receptor Information

>6az3 Chain A (length=254) Species: 5661 (Leishmania donovani)

GKTVLSCRKGNGSVYQVHGHKRLGPAKLRILDYAERHGYMRGVVKSIEHE
AGRGAALARVEFRHPYKFRRVKELMVAPEGMFTGQSVFCGQKAPLAIGNV
LPLGQITEGCIVCNVEAKPGDRGTLARASGDYCIIISHNHETGRTRLKLP
SGQKKSVPSTSRAMIGIISGGGRIEKPVLKAGNSFYRFRGKRNCWPKVRG
VARNPVEHPHGGGNHQHIGHPSTVSRHSPPGQKVGLIAARRTGRIRGGKA
VKGA

Ligand information

>6az3 Chain 2 (length=1078)

cccaacugcagaccguacucaucaccgcaucagguccccaagcauagaau
gcucugguacauagagaaagguacacucagggaagucggcaaaauagaug
cguaaguucgcaagaagcauuggcucugagggcaaaaauugccaacucag
aacugcuuacggcggggaauccaacuguauaauuaaaacauagguuugug
augcauccaagugguguauaucgcaaacugauuucugcccagugcucugu
gucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacua
ugacucucuuaagguagccaaaugccucgucuuccaauuagagacgcgca
ugaauggauuaaugagauucccucugucccgaguuacuaucuagcgaaac
gacagucaagggaacggacuugaagggcuaagcggggaaagaagacccug
uugaguuugacuccagucuggcucugugcggcgagcuucacuuaucgaau
gaagagaccaauggguuuagcguagucuuggcuaugcaccgucuagguuu
ccgugcuguaaacugaaccaacgggaaguuccggagucuuguuucgagac
aucugccagauggggaguuuggcuggggcggcauaucuguuacacgacaa
cgcagguguccuaaggcgagcucagugggaacagaaaucucacguagaac
acaagcguaaaagcuugcuugauuaacgauuuccaguacgaaucgagacu
gcgaaagcaaggccagcgauccuuugcgaagaauaggaaauaugaacaaa
ucauaccagaggugucagaauaauuaccacagggauaacuggcuuguggc
ggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucu
uccuaaccuagcgccgcagaagacgcuaaggguuggauuguucacccacu
gacagggaacgugagcuggguuuagaccgucgugagacagguugguuuua
cccuacuuagcuggaaauugcgagaaaaagauuauccguaagcggacgug
cgagcgguggguguacgguacgcucacc

........................<<......>>......<<<<<...>>
>>>........<<<<....<<<<.<<<<.<<...............<<<<
<....<....>.....>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>
>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<.
...<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<<.<<
<<....<<<<......>>>>....>>>>>>>>..>>>>><<<<<<.....
..>>>>>>........<...........<<<<<.......>>>>>.....
>.....>>.>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>.......
.....<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<
.<<<<<<..<<<<<.<<<<<<<...<<<.<<<..>>>.>>>...<<<<<.
....<<<<...........<.<<<..........>>>.>...........
.....................<<<<....>>>>..>>>>...>>>>>...
....>>>>>>>..>>>>>...<<<.....>>>..<<<<<<..........
.>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<
......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<
<<....>>>.>>........<<<<<<..............<<<<......
.>>>>.>>>>>>.........>>>>..>>>>>>.......<<.<...<<<
<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<
<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.........>>>..
...>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>.
.>>>.>>>>>>>......................<<.......>>.<.<>
.>.<.<<.....<<<...>>>..>>.>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6az3 Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): G2 S7 C8 G11 N12 G13 Q17 V18 G20 L24 P26 I31 Y34 R37 H38 Y40 R54 R64 Y67 K68 F69 R70 R71 G85 Q86 S87 F89 K93 P95 D122 R123 T125 L126 A127 R128 A129 S130 D132 L150 P151 S152 Q154 K156 G173 R174 I175 V179 L180 A182 S185 R193 W196 P197 K198 V199 R200 G201 V202 P206 H211 G213 G214 N215 H216 Q217 H218 I219 G220 P222 S223 T224 S226 R227 H228 P230 P231 G232 Q233 K234 V235 G236 L237 I238 A239 A240 R241 R242 T243 G244 R245 I246 K253 A255
• Binding residue (residue number reindexed from 1): G1 S6 C7 G10 N11 G12 Q16 V17 G19 L23 P25 I30 Y33 R36 H37 Y39 R53 R63 Y66 K67 F68 R69 R70 G84 Q85 S86 F88 K92 P94 D121 R122 T124 L125 A126 R127 A128 S129 D131 L149 P150 S151 Q153 K155 G172 R173 I174 V178 L179 A181 S184 R192 W195 P196 K197 V198 R199 G200 V201 P205 H210 G212 G213 N214 H215 Q216 H217 I218 G219 P221 S222 T223 S225 R226 H227 P229 P230 G231 Q232 K233 V234 G235 L236 I237 A238 A239 R240 R241 T242 G243 R244 I245 K252 A254

Gene Ontology

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UnboundLocalError

Python 3.6.8: /usr/bin/python3 Sat Nov 16 10:19:29 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1435     title=pdb2title(pdbid)

   1436     if bs.startswith("BS"):

=> 1437         pubmed,uniprot=display_interaction(pdbid,asym_id,bs,title)

   1438     else:

   1439         if lig3:

pubmed = '', uniprot = '', display_interaction = <function display_interaction>, pdbid = '6az3', asym_id = 'A', bs = 'BS02', title = 'Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.'

 /var/www/html/BioLiP/pdb.cgi in display_interaction(pdbid='6az3', asym_id='A', bs='BS02', title='Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.')

   1295         display_ec(ec,csaOrig,csaRenu)

   1296     if go:

=> 1297         display_go(go,uniprot,pdbid,asym_id)

   1298     return pubmed,uniprot

   1299 

global display_go = <function display_go>, go = '0003735,0005840,0006412', uniprot = '', pdbid = '6az3', asym_id = 'A'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0003735,0005840,0006412', uniprot='', pdbid='6az3', asym_id='A')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>