Structure of PDB 6ax3 Chain A Binding Site BS02

Receptor Information
>6ax3 Chain A (length=236) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSGVPRLHRPSLQHFREQFLVPGRPVILKGVADHWPCMQKWSLEYIQEIA
GCRTVPVEVGSRYTDEEWSQTLMTVNEFISKYIVNEPRDVGYLAQHQLFD
QIPELKQDISIPDYCSLGDGEEEEITINAWFGPQGTISPLHQDPQQNFLV
QVMGRKYIRLYSPQESGALYPHDTHLLHNTSQVDVENPDLEKFPKFAKAP
FLSCILSPGEILFIPVKYWHYVRALDLSFSVSFWWS
Ligand information
Ligand IDAKG
InChIInChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChIKeyKPGXRSRHYNQIFN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(=O)CCC(=O)O
OpenEye OEToolkits 1.7.6C(CC(=O)O)C(=O)C(=O)O
CACTVS 3.385OC(=O)CCC(=O)C(O)=O
FormulaC5 H6 O5
Name2-OXOGLUTARIC ACID
ChEMBLCHEMBL1686
DrugBankDB08845
ZINCZINC000001532519
PDB chain6ax3 Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6ax3 Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7.
Resolution2.25 Å
Binding residue
(original residue number in PDB)		Y272 W310 S318 H321 N327 K336 H400 V402 W414
Binding residue
(residue number reindexed from 1)		Y92 W130 S138 H141 N147 K156 H220 V222 W234
Annotation score5
Enzymatic activity
Enzyme Commision number 1.14.11.73: [protein]-arginine 3-hydroxylase.
3.4.-.-
External links
PDB RCSB:6ax3, PDBe:6ax3, PDBj:6ax3
PDBsum6ax3
PubMed29459673
UniProtQ8N371|KDM8_HUMAN Bifunctional peptidase and arginyl-hydroxylase JMJD5 (Gene Name=KDM8)

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