Structure of PDB 6as7 Chain A Binding Site BS02

Receptor Information
>6as7 Chain A (length=870) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EQVFHFYWLDAYEDQYNQPGVVFLFGKVWIESAETHVSCCVMVKNIERTL
YFLPREMKIDLNTGKETGTPISMKDVYEEFDEKIATKYKIMKFKSKPVEK
NYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTNTSSLELF
LMNRKIKGPCWLEVKSPQLLNQPVSWCKAEAMALKPDLVNVIKDVSPPPL
VVMAFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVS
KPKDCIFPYAFKEVIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGH
NIYGFELEVLLQRINVCKAPHWSKIGRLKRSNMPKLGFGERNATCGRMIC
DVEISAKELIRCKSYHLSELVQQILKTERVVIPMENIQNMYSESSQLLYL
LEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFL
LLHAFYENNYIVPDKQIFRKKAAYAGGLVLDPKVGFYDKFILLLDFNSLY
PSIIQEFNICFTTVQRVEQIPELPDPSLEMGILPREIRKLVERRKQVKQL
MKQQDLNPDLILQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTY
KGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSE
VNKLYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLD
IVRRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSV
PVSQFEINKALTKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYV
ICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPID
GIDAVLIATWLGLDPTQFRV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6as7 Activity and fidelity of human DNA polymerase alpha depend on primer structure.
Resolution2.95 Å
Binding residue
(original residue number in PDB)		S785 R834 A837 Y839 G841 G842 F962 K1051 R1222
Binding residue
(residue number reindexed from 1)		S444 R469 A472 Y474 G476 G477 F584 K673 R844
Binding affinityPDBbind-CN: Kd=58nM
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:1902975 mitotic DNA replication initiation

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Molecular Function
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Biological Process
External links
PDB RCSB:6as7, PDBe:6as7, PDBj:6as7
PDBsum6as7
PubMed29555682
UniProtP09884|DPOLA_HUMAN DNA polymerase alpha catalytic subunit (Gene Name=POLA1)

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