Structure of PDB 6ao5 Chain A Binding Site BS02

Receptor Information
>6ao5 Chain A (length=321) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DVLEKLGEGSYGSVFKAIHVVAIKQDLQEIIKEISIMQQCDSPYVVKYYG
SYFLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMR
KIHRNIKAGNILLNTEGHAKLADFGVAVIGTPFWMAPEVIQEIGYNCVAD
IWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTD
FVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHE
EQQRELEEEENWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELR
QRYTAKRQPILDAMDAKKRRQ
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6ao5 Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6ao5 SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.
Resolution2.955 Å
Binding residue
(original residue number in PDB)		N151 D164
Binding residue
(residue number reindexed from 1)		N110 D123
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) N146 K148 G150 N151 D164 T184
Catalytic site (residue number reindexed from 1) N105 K107 G109 N110 D123 T131
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6ao5, PDBe:6ao5, PDBj:6ao5
PDBsum6ao5
PubMed29063833
UniProtQ13188|STK3_HUMAN Serine/threonine-protein kinase 3 (Gene Name=STK3)

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