Structure of PDB 6anj Chain A Binding Site BS02

Receptor Information
>6anj Chain A (length=138) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GILDSMGRLENLGRIQFSVGYNFQESTLTVKVMKAQELPAKDFSGTSDPF
VKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYLQVL
DYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6anj Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6anj Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release.
Resolution1.698 Å
Binding residue
(original residue number in PDB)		K165 D166 D225 D227 D233
Binding residue
(residue number reindexed from 1)		K41 D42 D101 D103 D109
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005544 calcium-dependent phospholipid binding
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:6anj, PDBe:6anj, PDBj:6anj
PDBsum6anj
PubMed28923929
UniProtQ62747|SYT7_RAT Synaptotagmin-7 (Gene Name=Syt7)

[Back to BioLiP]