Structure of PDB 6ag4 Chain A Binding Site BS02

Receptor Information

>6ag4 Chain A (length=157) Species: 273057 (Saccharolobus solfataricus P2)

DFTLRNARMDDIDQIIKINRLTLPENYPYYFFVEHLKEYGLAFFVAIVDN
SVVGYIMPRIEWGFSNIKQLPSLVRKGAVVSIAVLEEYRRKGIATTLLEA
SMKSMKNDYNAEEIYLAVRVSNYPAIALYEKLNFKKVKVLKGYYADGEDA
YLMARPL

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 6ag4 Chain A Residue 203

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6ag4 Adaptation of thermophilic acetyltransferase to a water-mediated catalytic mechanism.
• Resolution: 2.256 Å
• Binding residue (original residue number in PDB): R129 N132
• Binding residue (residue number reindexed from 1): R119 N122
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.3.1.255: N-terminal amino-acid N(alpha)-acetyltransferase NatA.
  2.3.1.258: N-terminal methionine N(alpha)-acetyltransferase NatE.

Gene Ontology

Molecular Function

• GO:0004596 peptide alpha-N-acetyltransferase activity
• GO:0016746 acyltransferase activity
• GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
• GO:0046872 metal ion binding
• GO:0120518 peptide-methionine-alpha-N-acetyltransferase activity

Biological Process

• GO:0006474 N-terminal protein amino acid acetylation

Cellular Component

• GO:0005737 cytoplasm
• GO:0031415 NatA complex

External links

• PDB: RCSB:6ag4, PDBe:6ag4, PDBj:6ag4
• PDBsum: 6ag4
• PubMed: 32780067
• UniProt: Q980R9|NAT_SACS2 N-alpha-acetyltransferase (Gene Name=ard1)