Structure of PDB 6a9u Chain A Binding Site BS02

Receptor Information

>6a9u Chain A (length=405) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GELTPGISALEYYERRIRLAETLPPKSCVILAGNDIQYPFQQENDLFYLS
GWNEPNSVMILEKPTDSLSDTIFHMLVPPFRSGVYGVQEIFNADESASIN
DLSKYLPKIINRNEFIYFDMLSSSNFKHIKSLLDNKTIKPISKRIAEFRK
IKSPQELRIMRRAGQISGRSFNQAFAKRFRNERTLDSFLHYKFISGGCDK
DAYIPVVATGSNSLCIHYTRNDDVMFDDEMVLVDAAGSLGGYCADISRTW
PNSGKFTDAQRDLYEAVLNVQRDCIKLCKASNNYSLHDIHEKSITLMKQE
LKNLGIDKVSGWNVEKLYPHYIGHNLGLDVHDVPKVSRYEPLKVGQVITI
EPGLYIPNEESFPSYFRNVGIRIEDDIAIGEDTYTNLTVEAVKEIDDLEN
VMQNG

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

6a9u Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6a9u Crystal structures and biochemical analyses of intermediate cleavage peptidase: role of dynamics in enzymatic function.
Resolution	2.4 Å
Binding residue (original residue number in PDB)	D327 D338 H413 E467
Binding residue (residue number reindexed from 1)	D234 D245 H320 E374
Annotation score	4

Enzymatic activity

Enzyme Commision number

3.4.11.26: intermediate cleaving peptidase 55.

Gene Ontology

	Molecular Function
GO:0030145	manganese ion binding
GO:0070006	metalloaminopeptidase activity

View graph for
Molecular Function

External links

PDB	RCSB:6a9u, PDBe:6a9u, PDBj:6a9u
PDBsum	6a9u
PubMed	30582634
UniProt	P40051\|ICP55_YEAST Intermediate cleaving peptidase 55 (Gene Name=ICP55)

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