Structure of PDB 6a95 Chain A Binding Site BS02

Receptor Information
>6a95 Chain A (length=1307) Species: 6978 (Periplaneta americana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DKGRGANKDRDGSAHPDQALEQGSRLPARMRNIFPAELASTPLEDFDPFY
KNKKTFVVVTKAGDIFRFSGEKSLWMLDPFTPIRRVAISTMVQPIFSYFI
MITILIHCIFMIMPATQTTYILELVFLSIYTIEVVVKVLARGFILHPFAY
LRDPWNWLDFLVTLIGYITLVVDLGHLYALRAFRVLRSWRTVTIVPGWRT
IVDALSLSITSLKDLVLLLLFSLFVFAVLGLQIYMGVLTQKCVKHFPADG
SWGNFTDERWFNYTSNSSHWYIPDDWIEYPLCGNSSGAGMCPPGYTCLQG
YGGNPNYGYTSFDTFGWAFLSVFRLVTLDYWEDLYQLALRSAGPWHILFF
IIVVFYGTFCFLNFILAVVVMSYTHMVKRADEEKAAEREQGAIGAVVLSP
FFELFIAVIIVLNITFMALDHHDMNIEFERILRTGNYIFTSIYIVEAVLK
IIALSPKFYFKDSWNVFDFIIVVFAILELGLEGVQGLSVFRSFRLLRVFR
LAKFWPTLNNFMSVMTKSYGAFVNVMYVMFLLLFIFAIIGMQLFGMNYID
NMERFPDGDLPRWNFTDFLHSFMIVFRALCGEWIESMWDCMLVGDWSCIP
FFVAVFFVGNLVILNLLIALLLNNYRMWSNIRRVCFLLAKNKYFQKFVTA
VLVITSVLLALEDIYLPQRPVLVNITLYVDYVLTAFFVIEMIIMLFAVGF
KKYFTSKWYWLDFIVVVAYLLNFVLMCAGIEALQTLRLLRVFRLFRPLSK
VNGMQVVTSTLVEAVPHIFNVILVGIFFWLVFAIMGVQLFAGKFYKCVDE
NSTVLSHEITMDRNDCLHENYTWENSPMNFDHVGNAYLSLLQVATFKGWL
QIMNDAIDSREVHKQPIRETNIYMYLYFIFFIVFGSFFILKLFVCILIDI
FRQQRRKAEGLSATDSRTQLIYRRAVMRTMSAKPVKRIPKPTCHPQSLMY
DISVNRKFEYTMMILIILNVAVMAIDHYGQSMEFSEVLDYLNLIFIIIFF
VECVIKVSGLRHHYFKDPWNIIDFLYVVLAIAGLMLSDVIEKYFISPTLL
RILRILRVGRLLRYFQSARGMRLLLLALRKALRTLFNVSFLLFVIMFVYA
VFGMEFFMHIRDAGAIDDVYNFKTFGQSIILLFQLATSAGWDGVYFAIAN
EEDCRAPDHELGYPGNCGSRALGIAYLVSYLIITCLVVINMYAAVILDYV
LEVYEDSKEGLTDDDYDMFFEVWQQFDPEATQYIRYDQLSELLEALQPPL
QVQKPNKYKILSMNIPICKDDHIFYKDVLEALVKDVFSRRGSPVEAGDVQ
APNVDEA
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain6a95 Chain A Residue 1609 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6a95 Structural basis for the modulation of voltage-gated sodium channels by animal toxins.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		D375 E701 W702 I703 E704
Binding residue
(residue number reindexed from 1)		D329 E582 W583 I584 E585
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005261 monoatomic cation channel activity
GO:0005272 sodium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006814 sodium ion transport
GO:0019228 neuronal action potential
GO:0034220 monoatomic ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0086010 membrane depolarization during action potential
Cellular Component
GO:0001518 voltage-gated sodium channel complex
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034702 monoatomic ion channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6a95, PDBe:6a95, PDBj:6a95
PDBsum6a95
PubMed30049784
UniProtD0E0C2|SCNA1_PERAM Sodium channel protein PaFPC1

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