Structure of PDB 6a5o Chain A Binding Site BS02

Receptor Information
>6a5o Chain A (length=1408) Species: 644223 (Komagataella phaffii GS115) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQFPYSSAPLRSVKEVQFGLLSPEEIRAISVVKIEYPEIMDESRQRPREG
GLNDPKLGSIDRNFKCQTCGEGMAECPGHFGHMELAKPVFHIGFIPKIKK
VCECICMNCGKLLLDETNPTMAQAIRIRDPKKRFNAVWQLCKTKMVCEAD
APKVVSRGGCGNTQPVVRKDGMKLWGTWKKSRDAQPERKLLTPGEILNVF
KHISPEDCFRLGFNEDYARPEWMIITVLPVPPPQVRPSIAMDETTQGQDD
LTHKLSDILKANINVQKLEMDGSPQHIINEVEQLLQFHVATYMDNDIAGQ
PQALQKSGRPVKAIRARLKGKEGRLRGNLMGKRVDFSARTVISGDPNLEL
DQVGVPISIAKTLSYPETVTQYNIHRLTEYVRNGPNEHPGAKYVIRDNGD
RIDLRYHKRAGDIVLQYGWKVERHLMDDDPVLFNRQPSLHKMSMMAHRVK
VMPYSTFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAELSQLCAVPLQI
VSPQSNKPVMGIVQDTLCGVRKMTLRDTFIEYEQVMNMLFWVPSWDGVVP
QPAILKPKPLWTGKQLLSIAIPSGIHLQRTDGGNSLLSPKDNGMLIVDGK
VMFGVVDKKTVGSGGGGLIHTVMREKGPKICAELFGNIQKVVNYWLLHNG
FSIGIGDAIADASTMKEITHAISSAKEQVQEIIYKAQHNELELKPGMTLR
ESFEGEVSRTLNDARDSAGRSAEMNLKDLNNVKQMVSAGSKGSFINIAQM
SACVGQQMVEGKRIAFGFADRSLPHFTKDDFSPESKGFVENSYLRGLTPQ
EFFFHAMAGREGLIDTAVKTAETGYIQRRLVKALEDIMVHYDGTTRNSLG
DIIQFLYGEDGLDGTQVERQTIDTIPGSDKAFHKRYYVDLMDEKNSIKPD
VIEYAADILGDVELQKELNSEYEQLVSDRKFLREIVFVNGDHNWPLPVNL
RRIIQNAQQIFHLDRAKASDLTIPEIIHGVRDLCKKLFVLRGENELIKEA
QQNATSLFQCLVRARLATRRILEEFRLNRDAFEWVLGTIEAQFQRSLVHP
GEMVGVIAAQSIGEPATQMNVTLGVPRLKEILNVAKNIKTPALTVYLDRE
IALDIEKAKVIQSSIEYTTLKNVTSATEIYYDPDPTSTVIEEDFDTVEAY
FSQSPWLLRLELDRARMLDKQLTMNQVADKISEVFSDDLFVMWSEDNADK
LIIRCRVIEEDQMLKRIEAHMLDLIALRGIPGISKVYMVKHKVSVPDESG
EYKNEELWALETDGINLAEVMAVPGVDSSRTYSNSFVEILSVLGIEATRS
SLYKEILNVIAFDGSYVNYRHMALLVDVMTSRGYLMAITRHGINRADTGA
LMRCSFEETVEILFEAGAAAELDDCRGVSENVMLGQLAPMGTGAFDVMID
EKLLTSLP
Ligand information
>6a5o Chain T (length=178) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcagaatcccggtgccgaggccgctcaattggtcgtagacagctctagc
accgcttaaacgcacgtacgcgctgtcccccgcgttttaaccgccaaggg
gattacacccaagacaccaggcacgagacagaaaaaaacaacgaaaacgg
ccaccacccaaacacaccaaacacaaga
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6a5o Structural basis of the nucleosome transition during RNA polymerase II passage.
Resolution9.9 Å
Binding residue
(original residue number in PDB)		K318 K333 R345 R351 T832 A833 E1406 E1407 E1410
Binding residue
(residue number reindexed from 1)		K306 K321 R333 R339 T820 A821 E1357 E1358 E1361
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005665 RNA polymerase II, core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6a5o, PDBe:6a5o, PDBj:6a5o
PDBsum6a5o
PubMed30287617
UniProtC4R4Y0

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