Structure of PDB 5zwb Chain A Binding Site BS02

Receptor Information

>5zwb Chain A (length=271) Species: 28901 (Salmonella enterica)

DNHRALQTDIVAVQSQVVYGSVGNSIAVPAIKAQGLRVTAVPTVLFSNTP
HYKTFYGGIIPAEWFAGYLTALNERDALRELKAITTGYMGSADQIVLLSK
WLMAIRASHPEVCILVDPVIGDTDSGMYVQAEIPQAYRTHLLPQAQGLTP
NVFELEMLSGKPCRTLEEAVAAAQSLLSDTLKWVVITSAPGESLETITVA
VVTAQVVEVFAHPRVATELKGTGDLFCAELVSGIVQGKKLTTAAKDAAQR
VLEVMTWTQQCGCDELILPPA

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5zwb Chain A Residue 312

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5zwb Structural and functional studies on Salmonella typhimurium pyridoxal kinase: the first structural evidence for the formation of Schiff base with the substrate.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): T162 T200
• Binding residue (residue number reindexed from 1): T149 T187
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.1.35: pyridoxal kinase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003824 catalytic activity
• GO:0005524 ATP binding
• GO:0008270 zinc ion binding
• GO:0008478 pyridoxal kinase activity
• GO:0008902 hydroxymethylpyrimidine kinase activity
• GO:0016301 kinase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0009443 pyridoxal 5'-phosphate salvage
• GO:0016310 phosphorylation
• GO:0042816 vitamin B6 metabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:5zwb, PDBe:5zwb, PDBj:5zwb
• PDBsum: 5zwb
• PubMed: 31116912
• UniProt: A0A0F7J8S0