Structure of PDB 5zre Chain A Binding Site BS02

Receptor Information

>5zre Chain A (length=469) Species: 271848 (Burkholderia thailandensis E264) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

APRVRRSVRDLQKRYDNGEKKPLEDLVRAWVGIQALPPSDPKSFFALGGY
HGYCNHGNVLFPTWHRMYVYKLEEALQSIVPGVSMPFWDETDEYTLKHGI
PSILTQEKFELDGKQIDNPLRSFVLPVALSDRNIYEKPKGYVTVRYPLSG
LVGTPEALEQTKIHNAKFPLPEKNTELLNSNVRAWLKGDSPPDPTRNGVY
AKYVRCLSAPNYTVFSNTTSASVWNSSNPGLVTPVESPHNDIHLAVGGFD
YGQIAGANGDMGENNTAGMDPIFFFHHCNVDRMFWVWQKQTGHTDRLDII
RNYPGTNAESLNLTTPLNPFKKASGEAYTSEDCINIERQLGFTYGPGSLD
DATPELKSLLAVPSGNSTKKLTVTGIDRAQIQGSFIMKAYASVTDANGKT
REYYLGHKSILSRWNLDIVAHFPLSAMPADDVPKAKFRVEFIHRGGGVPS
AAKAAIDKVSALQPKFEVS

Ligand information

Ligand ID

InChI

InChI=1S/Cu/q+2

InChIKey

JPVYNHNXODAKFH-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Cu+2]
CACTVS 3.341	[Cu++]

Formula

Name

COPPER (II) ION

PDB chain

5zre Chain A Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5zre Structural Basis for Highly Efficient Production of Catechol Derivatives at Acidic pH by Tyrosinase from Burkholderia thailandensis
Resolution	2.5 Å
Binding residue (original residue number in PDB)	H56 H84 H93
Binding residue (residue number reindexed from 1)	H51 H56 H65
Annotation score	1

Enzymatic activity

Enzyme Commision number

1.14.18.1: tyrosinase.

Gene Ontology

	Molecular Function
GO:0004497	monooxygenase activity
GO:0004503	tyrosinase activity
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

View graph for
Molecular Function

External links

PDB	RCSB:5zre, PDBe:5zre, PDBj:5zre
PDBsum	5zre
PubMed
UniProt	Q2T7K1

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