Structure of PDB 5zqf Chain A Binding Site BS02

Receptor Information
>5zqf Chain A (length=708) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFP
LRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGK
IMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKALSFYS
IPEFDEWKKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAIT
LAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYKHLTYNDFINKELI
LFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEM
SAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPR
YIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAE
GIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQ
NQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALI
SDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFD
HMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARF
ILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEGPDFNYILN
MSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDK
VESQERED
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5zqf Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.
Resolution3.873 Å
Binding residue
(original residue number in PDB)		R503 K505 L507 N508 H564 R677 K678 I872 G873 T874 G875 W876 A877 T1010 L1011 T1012 N1014 S1015
Binding residue
(residue number reindexed from 1)		R52 K54 L56 N57 H113 R211 K212 I402 G403 T404 G405 W406 A407 T540 L541 T542 N544 S545
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:5zqf, PDBe:5zqf, PDBj:5zqf
PDBsum5zqf
PubMed30082834
UniProtQ02880|TOP2B_HUMAN DNA topoisomerase 2-beta (Gene Name=TOP2B)

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