Structure of PDB 5zon Chain A Binding Site BS02

Receptor Information

>5zon Chain A (length=256) Species: 83332 (Mycobacterium tuberculosis H37Rv)

HDDLMLALALADRADELTRVRFGALDLRIDTKPDLTPVTDADRAVESDVR
QTLGRDRPGDGVLGEEFGGSTTFTGRQWIVDPIDGTKNFVRGVPVWASLI
ALLEDGVPSVGVVSAPALQRRWWAARGRGAFASVDGARPHRLSVSSVAEL
HSASLSFSSLSGWARPGLRERFIGLTDTVWRVRAYGDFLSYCLVAEGAVD
IAAEPQVSVWDLAALDIVVREAGGRLTSLDGVAGPHGGSAVATNGLLHDE
VLTRLN

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 5zon Chain A Residue 302

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5zon Identification and structural characterization of a histidinol phosphate phosphatase from Mycobacterium tuberculosis
• Resolution: 1.94 Å
• Binding residue (original residue number in PDB): E67 D83 D213
• Binding residue (residue number reindexed from 1): E65 D81 D211
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.3.15: histidinol-phosphatase.

Gene Ontology

Molecular Function

• GO:0004401 histidinol-phosphatase activity
• GO:0008934 inositol monophosphate 1-phosphatase activity
• GO:0016787 hydrolase activity
• GO:0016791 phosphatase activity
• GO:0042578 phosphoric ester hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0000105 L-histidine biosynthetic process
• GO:0010125 mycothiol biosynthetic process

Cellular Component

• GO:0005829 cytosol
• GO:0005886 plasma membrane

External links

• PDB: RCSB:5zon, PDBe:5zon, PDBj:5zon
• PDBsum: 5zon
• PubMed: 29752410
• UniProt: P95189|HISN_MYCTU Histidinol-phosphatase (Gene Name=hisN)