Structure of PDB 5zoe Chain A Binding Site BS02

Receptor Information
>5zoe Chain A (length=290) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGD
VLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKVKVTKQHNDECKH
LLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMACLTFGSPVLMRH
LTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGP
KRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPES
VELKWSEPNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5zoe Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		Q48 L53 Q54 T61 M65 K314 Q315 F316 S317 R320
Binding residue
(residue number reindexed from 1)		Q47 L52 Q53 T60 M64 K271 Q272 F273 S274 R277
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds

View graph for
Molecular Function
External links
PDB RCSB:5zoe, PDBe:5zoe, PDBj:5zoe
PDBsum5zoe
PubMed30295841
UniProtP39748|FEN1_HUMAN Flap endonuclease 1 (Gene Name=FEN1)

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